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UKHSA's Dose Calculation Service provides a full radiation dose calculation report, suitable for submission to appropriate international authorities as part of an application for a licence to administer radiolabelled medicinal products to patients or volunteers in clinical trials. Such an application is required in the UK under Regulation 5 of the Ionising Radiation (Medical Exposure) Regulations 2017.
UKHSA has been providing radiation dose estimates to pharmaceutical companies wanting to administer radiolabelled drugs to human volunteers for research purposes for over 30 years.
The Dose Calculation Service is a service offered by UKHSA and has absolutely no influence or involvement in the deliberations of the Administration of Radioactive Substances Advisory Committee (ARSAC) and its recommendations to Ministers.
When you apply for a licence to administer radiolabelled medicinal products to patients or volunteers in clinical trials you need to include estimates of effective dose based on the best information available at the time.